The high efficiency air filtration device of biosafety type (hereinafter referred to as HEPA filtration device) is a ventilation filtration device specially used in the field of biosafety, which is internally installed with high efficiency air filter (hereinafter referred to as HEPA filtration device Filter) is one of the most important secondary protective barriers in the biosafety laboratory, which can effectively prevent the biological aerosols in the laboratory from leaking to the outdoor environment. The SARS epidemic in 2003 and the acquired SARS infection in 2004 exposed the shortcomings of the construction of biosafety laboratories in China, which attracted the attention of the whole society and government departments. In 2004, GB 1948-2004 "General requirements for laboratory biosafety" was officially released, marking that the construction, operation and management of biosafety laboratories in China have entered a standardized and scientific development path. GB 1948 9-2008 "General requirements for laboratory biosafety" focuses on Revising the requirements for HEPA filter of exhaust air. At that time, China had not yet realized the localization of related technologies and products, which effectively promoted the research and development of HEPA filtration device and related technologies in China.
After more than 10 years of development, HEPA filtration device has realized localization and original innovation of core technology, which has been successfully applied in a wide range of high-level biosafety laboratories in China. This paper introduces the development of HEPA filter, summarizes the development process and achievements of HEPA filter in China, and puts forward some suggestions for the subsequent revision of GB 1948 9.
The air-cooled / water-cooled direct expansion Inverter clean air conditioning produced by Guangdong headpower Air Conditioning Co., Ltd. is widely used in various levels of biological laboratories, isolation wards, ventilator production workshops, and mask production clean workshops. The unit can be adjusted with constant temperature and humidity, with high temperature accuracy and humidity accuracy. The direct-current Inverter compressor is selected, and the refrigeration capacity can be adjusted with variable frequency.
Application of air-cooled direct expansion variable frequency constant temperature and humidity clean air conditioning produced by Guangdong headpower Air Conditioning Co., Ltd. and Guangdong Pharmaceutical Research Institute
GB 1948 9-2008 mainly revised the requirements of HEPA filter for exhaust air, involving two parts: 1) in situ leak detection and disinfection of filter; 2) installation position. The details are as follows:
GB 1948 9-2008 clearly stipulates that "the HEPA filter of exhaust air can be disinfected and leak detected in situ".
The results show that under the condition of reasonable design, the "up feed up row" and "up feed down row" can form a directional trend flow, and the difference between them is not obvious. At the same time, due to the characteristics of simple construction and easy maintenance, the air distribution mode of "up, up and down" has been widely used in foreign high-level biosafety laboratories. Therefore, GB 1948 9-2008 deleted the mandatory requirement that the air distribution of high-level biosafety laboratory must adopt "up, down and down".
The newly built laboratory urgently needs to develop HEPA filtration device that conforms to the international advanced concept. The box type HEPA filtration device with leak detection and disinfection function has been used in high-level biosafety laboratories in foreign countries since 1980s. After the promulgation of GB 1948-2008, China's newly-built Laboratories began to adopt foreign advanced design concepts, such as setting up a high equipment layer to facilitate equipment maintenance. However, at that time, China had no matched HEPA filter device, and the technical reserve was insufficient, almost entirely dependent on imports, which severely restricted the development of China's high-level biosafety laboratories.
There is an urgent need to develop HEPA filter which can meet the structural conditions of the existing laboratory. According to statistics, there are nearly 60 high-level pathogenic microorganism laboratories built or basically built in China in 2008, almost none of which can be installed with box HEPA In the equipment layer of the filter device, there is a hidden danger that the laboratory that has passed the accreditation can not pass the re evaluation after the expiration of 5 years, such as waste reconstruction, which will cause serious waste and weaken the ability of disease prevention and control in a period of time. In order to meet the needs of national major infectious disease prevention and control for high-level pathogenic microorganism laboratories, it is urgent to solve the technical problems of making these high-level biosafety laboratories meet the requirements of GB 1948 9-2008 through transformation.